GENTAUR BVBA
VAT BE0473327336
Av. de l Armee 68 B4
1040 Brussels
BELGIUM
Tel + 32 16 58 90
45
Fax + 32 16 50 90 45
GENTAUR France SARL
SIRET 48423788800017
Rue Lagrange, 9
75005 Paris,
France
Tel 01 43 25 01 50
Fax 01 43 25 01 60
GENTAUR Germany
52074 Aachen,
Germany
Tel
0241 40 08 90 86
Fax 0241 55 91
05 36
 GENTAUR
Pol Sp. Z.o.o. Ulica
Ogarna 15/19B m2
80-826 GDANSK
Tel 00 48 51 760 77
08
Fax: 00 32 16 50 90
45
GENTAUR Italy
23015 Milano, Italy
Tel 02 36 00 65
93
Fax 02 36 00 65
94
Česká republika
Praha
+420246019719
Danmark
+4569918806
Finland Helsset
+358942419041
Ελλάς Αθήνα
+302111768494
Ireland Dublin
+35316526556
Luxembourg
+35220880274
Magyarország
Budapest
+3619980547
Nederland
+31208080893
 Norge
Oslo
+4721031366
Österreich
+43720880899
 Sverige
Stockholm
+46852503438
Schweiz Züri
+41435006251
Northern America
Canada Montreal
+15149077481
US New York
+17185132983
Other Countries
0032 (0)16 41 44 07 |
|
|
|
|
|
|
| |
RNAI Libraries
RNAi Clone Library targeting
all annotated genes in the human and mouse genomes.
Background:
Recent work has identified that a conserved biological response to
double-stranded RNA, known as RNA interference (RNAi), specifically silences
protein-coding genes through degradation of homologous mRNAs. Scientists at Cold
Spring Harbor Laboratory (CSHL) have exploited this natural process to
efficiently and cost-effectively probe gene function through targeted RNAi-induction.
RNAi Clone Library:
Scientists in the Hannon Lab at CSHL are generating an RNAi Clone
Library consisting of at least 3 siRNAs specifically targeting every annotated
gene in the human and mouse genomes. By allowing for selective silencing of any
gene in the genome, these large-scale libraries of RNAi-inducing plasmids
provide a powerful tool for systematically probing gene function on a whole
genome scale and introduce novel methods to screen for potential therapeutic
targets associated with diseases ranging from HIV to cancer.
Greg Hannon is an expert in the areas of post-transcriptional gene silencing
and RNAi. His laboratory has been responsible for many of the seminal
discoveries that uncovered the role of RNAi in normal cell physiology. For a
more detailed explanation of RNAi and the potential of this technology please
refer to his most recent articles “Short hairpin RNAs (shRNAs) induce sequence-specific
silencing in mammalian cells.” (Genes Dev. 2002; 16, 948-958), “Germline
transmission of RNAi” (Nat Struct Biol. 2003; 10, 91-92) and “An epi-allelic
series of p53 hypomorphs created by stable RNAi produces distinct tumor
phenotypes in vivo.” (Nat Genet. 2003; 33, 396-400).
Applications:
The ability to generate RNAi-inducing clones individually target
specific genes in the human genome will permit rapid, cost-efficient, loss-of -function
genetic screens and rapid tests for genetic interactions to be performed in
mammalian cells. Such approaches hold tremendous promise for unleashing the
dormant potential of sequenced genomes and provide drug companies and individual
researchers with an efficient means to help locate gene targets involved in any
disease of interest.
|
日本